8th International Symposium on Coagulation in Liver Disease

Sept 27th-28th 2019, Groningen, The Netherlands


Organisers : Ton Lisman (Groningen NL), Robert Porte (Groningen, NL), Nicolas Intagliata (Charlottesville, VA, USA), Stephen Caldwell (Charlottesville, VA, USA)

Curriculum advisors: Juan-Carlos Garcia-Pagan (Barcelona, Spain), Patrick Northup (Charlottesville, VA, USA), Craig Jenne (Calgary, Canada), James Luyendyk (East Lansing, MI, USA)


Friday, Sept 27


9:00 – 9:15      Welcome(‘Blauwe Zaal’) Ton Lisman (Groningen NL) & Stephen Caldwell (Charlottesville, VA, USA)

9:15 – 9:50      Keynote lecture 1 – Translational research on CILD: knowns and unknowns – Ton Lisman (Groningen NL)


Session 1 – Magnitude of the clinical problems

Moderators: Edoardo Giannini and Patrick Northup

9:50 – 10:15    Incidence of procedural bleedingJonel Trebicka (Bonn, Germany)

10:15 – 10:40  Incidence of bleeding and thrombosis in ALFTodd Stravitz (Richmond, VA, USA)

Tea and Coffee at the ‘Blauwe Patio’

11:05 – 11:30  Incidence of bleeding and thrombosis in acutely ill cirrhotics William Bernal (London, UK)

11:30 – 11:55  Patient Blood Management, use of blood for transfusion and alternatives in patients with liver disease: what is new? Simon Stanworth (Oxford, UK)


11:55 Posters and lunch at the ‘Blauwe Patio’


13:00 – 14:00 Oral Abstract Presentations

Oral Abstract Presentations

13:00 Fresh frozen plasma transfusion in patients with cirrhosis and coagulopathy: effect on thrombomodulin-modified thrombin generation – Alberto Farias

13:15 Conventional coagulation parameters do not predict procedure – related bleeding in Cirrhosis – Natasha Janko

13:30 Von Willebrand factor delays repair of acetaminophen-induced liver injury in mice by stabilizing hepatic platelet aggregates – Dafna Groeneveld

13:45 Patients with chronic liver disease do not have impaired thrombin generation potential in whole blood nor in plasma – Jun Wan


Session 2 – Management of bleeding and thrombosis


Moderators: Pierre Emmanuel Rautou and Stephen Caldwell

14:00 – 14:35  Keynote lecture 2 – TPO receptor agonists – what do they deliver? – Norah Terrault (San Francisco, CA, USA)

14:35 – 15:00  Thromboprophylaxis – is it needed? Is it effective?Patrick Northup (Charlottesville, VA, USA)


15:00 Tea and Coffee at the ‘Blauwe Patio’


15:45 – 16:05  Modeling of efficacy of pro- and anticoagulants Ton Lisman (Groningen, NL)

16:05 – 16:30  Cirroxaban study Juan-Carlos Garcia-Pagan (Barcelona, Spain)

16:30 – 16:55  Edoxaban studySarah Bos (Groningen, NL)

16:55 Drinks at the ‘Blauwe Patio’

The drinks are offered to you by the University of Groningen, Municipality and Province of Groningen

18:30 Conference ‘walking dinner’ at the Groninger Museum


Saturday, September 28

08:30 Registration and tea/coffee at the UMCG (‘Blauwe Patio’)

 Session 3 – Portal vein thrombosis

Moderators: Marco Senzolo and Nicolas Intagliata

9:00 – 9:35      Keynote lecture 3 – PVT – an overview – Nicolas Intagliata (Charlottesville, VA, USA)

9:35 – 10:00    Predictors of cirrhotic PVTJuan-Carlos Garcia-Pagan (Barcelona, Spain)

10:00 – 10:25  HCV treatment – effects on coagulation and PVT riskPaolo Simioni (Padua, Italy)

10:25 Tea and Coffee at the ‘Blauwe Patio’

10:40 – 11:05  Transient portal vein thrombosisDominique Valla (Clichy, France)

11:05 – 11:30  Recurrent portal vein thrombosisFrancesco Violi (Roma, Italy)

11:30 – 11:55  Invasive therapies for portal vein thrombosis Ziv Haskal (Charlottesville, VA, USA)

11:55 – 12:20  A surgeon’s perspective on cirrhotic portal vein thrombosisNigel Heaton (London, UK)


12:20 Lunch and posters at the ‘Blauwe Patio’


Session 4 – New players and mechanisms

Moderators: Shiv Sarin and Craig Jenne

13:30 – 14:05  Keynote lecture 4 – TGA, TEG, ROTEM, Sonorheometry – what do they deliver? – Neeral Shah (Charlottesville, VA, USA)

14:05 – 14:30  Thrombin and fibrin in progression of fatty liver diseaseMatthew Flick (Cincinnati, OH, USA)

14:30 – 14:55  The endothelium in cirrhotic thrombosisVirginia Hernández-Gea (Barcelona, Spain)

14:55 – 15:20  Hemostasis and liver regeneration – experimental perspective James Luyendyk (East Lansing, MI, USA)

15:20 Tea and Coffee at the ‘Blauwe Patio’

15:45 – 16:10  Hemostasis and liver regeneration – human perspectivePatrick Starlinger (Vienna, Austria)

16:10 – 16:35  NETs and coagulationFien von Meijenfeldt (Groningen, NL)

16:35 – 17:00  Anticoagulation and the risk of fibrin formation during ex-situ machine perfusion of donor livers for transplantationRobert Porte (Groningen, NL)

Closing remarks, plans for future studies, plans for 2021 symposium – Stephen Caldwell & Ton Lisman

17:30 Adjourn